Research Publications and Projects
Lipoedema cells are different to obesity
Groundbreaking Australian Research- 2021
Key signaling networks are dysregulated in patients with the adipose tissue disorder, lipedema
Authors: Musarat Ishaq, Nadeeka Bandara, Steven Morgan, Cameron Nowell, Ahmad M. Mehdi, Ruqian Lyu, Davis McCarthy, Dovile Anderson, Darren J. Creek, Marc G. Achen, Ramin Shayan and Tara Karnezis.
Led by Dr Tara Karnezis and Associate Professor Ramin Shayan, the Australian team found that people with Lipoedema have stem cells that differ from those in normal fat, in almost every way.
Their research identified a gene involved in cellular growth within the abnormal lipoedema stem cells, which can drive more stem cells to form more fat cells. By introducing drugs that inhibit this gene pathway, the team was then able to block fat stem cell growth to a baseline or ‘normal’ level, showing the potential for treatment.
“For years, I have lived with lipoedema, and been told that diet and exercise was the path to better health. Now, science is starting to explain why I could never curb my body’s excess fat production through lifestyle controls. I am not obese and have a real medical condition that needs treatment. This research is exactly the kind of breakthrough that people like me have been waiting for. It provides renewed hope for me, that my children may not have to suffer the way I have suffered all my life.” Nola Young, Chair Lipoedema Australia.
Ongoing German study compares results of Liposuction with conventional treatments
A randomised controlled multicentre investigator-blinded clinical trial comparing efficacy and safety of surgery versus complex physical decongestive therapy for lipedema (LIPLEG) 2021
Authors: Maurizio Podda, Maximilian Kovacs, Martin Hellmich, Rebecca Roth, Marouan Zarrouk, Daria Kraus, Reinhild Prinz-Langenohl and Oliver A. Cornely.
LIPLEG assesses whether surgical treatment of lipedema is safe and effective to reduce pain and other lipedema-related health issues. The findings of this important German trial have the potential to change the standard of care in lipedema.
The LIPLEG trial evaluates the efficacy and safety of liposuction compared to standard CDT (complex physical decongestive therapy).
The trial is conducted in accordance with the Inter- national Conference on Harmonisation for Good Clinical Practice (ICH-GCP). The trial will always comply with the Declaration of Helsinki. The results of this trial will be submitted for publication in peer-reviewed scientific journals and presented at national and international conferences.
Recruitment of participants started in December 2020 and last patient’s last visit is expected in summer 2025.
Management of Lipedema with Ketogenic Diet: 22-Month Follow-Up 2021
Authors: Roberto Cannataro, Sandro Michelini, Lorenzo Ricolfi, Maria Cristina Caroleo, Luca Gallelli, Giovambattista De Sarro, Alberto Onorato and Erika Cione.